Statistical Bioinformatics Seminar: Trinh -- Integrative Single Cell Omics Analysis of Breast Cancer

The transition from early breast cancer (ductal carcinoma in situ: DCIS) to invasive
breast cancer (invasive ductal carcinoma: IDC) is an evolutionary bottleneck where
progression occurs only in 30% of patients. However, the molecular processes marking
this transition remain poorly understood. We profile the DCIS to IDC transition
from an integrated in situ and immunogenomics standpoint, using a combination of
exome sequencing, RNA-sequencing and cyclic immunofluorescence. I will discuss
how the tumor and immune system can collectively influence tumour evolution:
firstly, the role of immunosurveillance in shaping the evolutionary trajectory of
the tumour, and secondly, how genomic changes in tumour cells including oncogenic
hotspot mutations can contribute to immune escape.